In multiple sclerosis, oligoclonal bands connect to peripheral B‐cell responses
نویسندگان
چکیده
منابع مشابه
In multiple sclerosis, oligoclonal bands connect to peripheral B-cell responses
OBJECTIVE To determine to what extent oligoclonal band (OCB) specificities are clonally interrelated and to what degree they are associated with corresponding B-cell responses in the peripheral blood (PB) of multiple sclerosis (MS) patients. METHODS Mass-spectrometric proteomic analysis of isoelectric focused (IEF) cerebrospinal fluid (CSF) immunoglobulin G (IgG) was used in combination with ...
متن کاملCSF -- oligoclonal bands in multiple sclerosis.
The present paper is concerned with a correlation between clinical parameters of multiple sclerosis and different agar gel electrophoretical patterns in CSF. The agar gel electrophoresis represents clearly the most sensitive method for the demonstration of oligoclonal bands in CSF.
متن کاملReibergram and oligoclonal bands in diagnosis of multiple sclerosis.
INTRODUCTION In this study authors have analyzed the correlation between the IgG immunoglobulins in cerebrospinal fluid and the findings of oligoclonal bands on gel. Immunoglobulin IgG in cerebrospinal fluid (CSF) can be detected in neurological diseasses (infections and inflammatory neurological diseases and in demyelinating diseases, like multiple sclerosis (MS)). Quantitative IgG in CSF can ...
متن کاملAntibodies in multiple sclerosis oligoclonal bands target debris.
IgG oligoclonal bands (OCB) are detected in the cerebrospinal fluid (CSF) of more than 90% of multiple sclerosis (MS) patients and are considered the immunological hallmark that supports MS diagnosis. OCB are not unique to MS but are also observed in chronic CNS infections, where they target their causative agents (1–3). However, the target specificities of the IgG within OCB in MS have remaine...
متن کاملMore on oligoclonal bands and diagnosis of multiple sclerosis.
A When we consider that creatinine and uric acid, for example, are excreted in concentrations of about 15 and 5 mmoLfL, we can already observe positive biases caused by these interferencesat a sample:reagent volume ratio of 1:5 (1). However, this ratio does not yet permit measurement of microalbuminuria. Thus, the interferingreactions of urinary components with bromphenol blue preclude use of t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2014
ISSN: 0364-5134,1531-8249
DOI: 10.1002/ana.24088